Publication Date:
1991-10-18
Description:
One of the first zygotically active genes required for formation of the terminal domains of the Drosophila embryo is tailless (tll). Expression of the tll gene is activated ectopically in gain-of-function mutants of the maternal terminal gene torso (tor); this suggests that tor normally activates the tll gene in the termini. Ectopic expression of tll under the control of an inducible promoter results in differentiation of ectopic terminal-specific structures, the Filzkorper, and leads to the activation of at least one gene, hunchback, that is required to form these structures. Ectopic expression of the tll gene also represses segmentation by repressing the gap genes Kruppel and knirps and probably also pair rule genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steingrimsson, E -- Pignoni, F -- Liaw, G J -- Lengyel, J A -- 09948/PHS HHS/ -- New York, N.Y. -- Science. 1991 Oct 18;254(5030):418-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Los Angeles 90024.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925599" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Drosophila/embryology/*genetics
;
Embryonic Development
;
Female
;
Genes, Regulator
;
Heat-Shock Proteins/genetics
;
Hot Temperature
;
Male
;
Mutation
;
Phenotype
;
Promoter Regions, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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