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Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification (1984)

D. K. Biswas ; J. A. Hartigan ; M. H. Pichler

American Association for the Advancement of Science (AAAS)

In: Science. 225(4665): 941-3.

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Publication Date: 1984-08-31

Description: Bromodeoxyuridine (BrdUrd) treatment of the prolactin nonproducing subclone of GH cells (rat pituitary tumor cells) induces amplification of a 20-kilobase DNA fragment including all of the prolactin gene coding sequences. This amplified DNA segment, which is flanked by two unamplified regions, thus designates a unit of BrdUrd-induced amplified sequence. Cloned DNA segments, 10.3 kilobases long, from the 5' end of the rat prolactin gene of BrdUrd-responsive and -nonresponsive cells, were ligated to the thymidine kinase gene of herpes simplex virus type 1 (HSV1TK), and the hybrid DNA was transferred to thymidine kinase-deficient mouse fibroblast cells by transfection. The HSV1TK gene and the rat prolactin gene were amplified together in drug-treated transfectants carrying the hybrid DNA HSV1TK gene and rat prolactin gene of BrdUrd-responsive GH cells. These results suggest that the 10.3-kilobase DNA segment at the 5' end of the rat prolactin gene of BrdUrd-responsive GH cells carries the information for drug-induced gene amplification (amplicon) and that another gene, such as the HSV1TK gene, is also amplified when the latter is placed adjacent to this segment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biswas, D K -- Hartigan, J A -- Pichler, M H -- CA28218/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):941-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089335" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; Base Sequence ; Bromodeoxyuridine/*pharmacology ; Cell Line ; Cloning, Molecular ; DNA/*genetics ; DNA, Recombinant ; *Gene Amplification ; Genes, Viral ; Mice ; Prolactin/genetics ; Rats ; Simplexvirus/genetics ; Thymidine Kinase/genetics ; Transfection

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Clustering (1973)

Hartigan, J A

Palo Alto, Calif. : Annual Reviews

Annual Review of Biophysics and Biomolecular Structure 2 (1973), S. 81-102

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ISSN: 0084-6589

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Biology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.bb.02.060173.000501

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Electronic Resource

The MAP test for multimodality (1994)

Rozál, Gregory Paul M. ; Hartigan, J. A.

Springer

Journal of classification 11 (1994), S. 5-36

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ISSN: 1432-1343

Keywords: Minimal constrained spanning trees ; Nearest neighbor density estimates ; Minimal ascending path spanning trees ; Tests for modes ; The MAP test

Source: Springer Online Journal Archives 1860-2000

Topics: Mathematics

Notes: Abstract We introduce a test for detecting multimodality in distributions based on minimal constrained spanning trees. We define a Minimal Ascending Path Spanning Tree (MAPST) on a set of points as a spanning tree that has the minimal possible sum of lengths of links with the constraint that starting from any link, the lengths of the links are non-increasing towards a root node. We define similarly MAPSTs with more than one root. We present some algorithms for finding such trees. Based on these trees, we devise a test for multimodality, called the MAP Test (for Minimal Ascending Path). Using simulations, we estimate percentage points of the MAP statistic and assess the power of the test. Finally, we illustrate the use of MAPSTs for determining the number of modes in a distribution of positions of galaxies on photographic plates from a rich galaxy cluster.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01201021

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Bloc Voting in the United States Senate (2000)

Hartigan, J. A.

Springer

Journal of classification 17 (2000), S. 29-49

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ISSN: 1432-1343

Source: Springer Online Journal Archives 1860-2000

Topics: Mathematics

Notes: blocs and legislative measures are partitioned into types so that, as nearly as possible, votes by each bloc for each type of measure are either all YEAs or all NAYs. A probability model is given for the partitions into blocs and types, and for the pattern of YEAs and NAYs given the partitions. The Alternating Randomized Combination algorithm is presented for searching for high probability partition pairs. The probability of each bloc and type in the final optimal partition pair is estimated by Markov Chain Monte Carlo. The final partition identifies 18 blocs of Senators, and 14 types of legislative measures. The blocs and types are delineated in a table reporting all decisive votes in the 103rd Congress. The blocs are characterized by the types of measures in which they vote against the majority party.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s003570000003

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Electronic Resource

Statistical theory in clustering (1985)

Hartigan, J. A.

Springer

Journal of classification 2 (1985), S. 63-76

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ISSN: 1432-1343

Keywords: Theory of clustering ; High density clusters ; Tests of unimodality

Source: Springer Online Journal Archives 1860-2000

Topics: Mathematics

Notes: Abstract A number of statistical models for forming and evaluating clusters are reviewed. Hierarchical algorithms are evaluated by their ability to discover high density regions in a population, and complete linkage hopelessly fails; the others don't do too well either. Single linkage is at least of mathematical interest because it is related to the minimum spanning tree and percolation. Mixture methods are examined, related to k-means, and the failure of likelihood tests for the number of components is noted. The DIP test for estimating the number of modes in a univariate population measures the distance between the empirical distribution function and the closest unimodal distribution function (or k-modal distribution function when testing for k modes). Its properties are examined and multivariate extensions are proposed. Ultrametric and evolutionary distances on trees are considered briefly.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01908064

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