Publication Date:
1979-10-12
Description:
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/*metabolism
;
Animals
;
Calcium/*physiology
;
Calcium-Binding Proteins/*metabolism
;
Calmodulin/*metabolism
;
Cell Membrane/metabolism
;
Cyclic AMP/metabolism
;
Egtazic Acid/metabolism
;
Enzyme Activation
;
Female
;
Glucose/pharmacology
;
Insulin/*secretion
;
Islets of Langerhans/*enzymology
;
Kinetics
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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