Publication Date:
1983-10-14
Description:
Improved liquid ion-exchanger microelectrodes made possible the observation of large, rapid decreases in the concentration of extracellular calcium ions during single epileptic spikes. Moreover, in definite cortical layers the decreases regularly started shortly before the onset of each epileptic spike. In view of the prominent role played by extracellular calcium ions in neuronal processes, including transmitter release and membrane excitability, these alterations probably exert a profound influence on the cellular events underlying epileptiform activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pumain, R -- Kurcewicz, I -- Louvel, J -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623068" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Calcium/*physiology
;
Cerebral Cortex/physiopathology
;
Epilepsy/chemically induced/*physiopathology
;
Extracellular Space/physiology
;
Penicillins
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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