Publication Date:
2010-01-09
Description:
Stem cell niches are locations where stem cells reside and self-renew. Although studies have shown how niches maintain stem cell fate during tissue homeostasis, less is known about their roles in establishing stem cells. The adult Drosophila midgut is maintained by intestinal stem cells (ISCs); however, how they are established is unknown. Here, we show that an ISC progenitor generates a niche cell via Notch signaling. This niche uses the bone morphogenetic protein 2/4 homolog, decapentaplegic, to allow progenitors to divide in an undifferentiated state and subsequently breaks down and dies, resulting in the specification of ISCs in the adult midgut. Our results demonstrate a paradigm for stem cell-niche biology, where progenitors generate transient niches that determine stem cell fate and may give insights into stem cell specification in other tissues.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857772/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857772/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathur, Divya -- Bost, Alyssa -- Driver, Ian -- Ohlstein, Benjamin -- R01 DK082456/DK/NIDDK NIH HHS/ -- R01 DK082456-01/DK/NIDDK NIH HHS/ -- T32 GM007088/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 8;327(5962):210-3. doi: 10.1126/science.1181958.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056890" target="_blank"〉PubMed〈/a〉
Keywords:
Adult Stem Cells/*cytology/physiology
;
Animals
;
Cell Differentiation
;
Cell Lineage
;
Cell Proliferation
;
Drosophila/*cytology/growth & development/metabolism
;
Drosophila Proteins/genetics/metabolism
;
Enterocytes/cytology
;
Epithelial Cells/*cytology
;
Intestines/cytology/growth & development
;
Larva/cytology/growth & development/metabolism
;
Metamorphosis, Biological
;
Organogenesis
;
Receptors, Notch/metabolism
;
Signal Transduction
;
Stem Cell Niche/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink