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  • 1
    Electronic Resource
    Electronic Resource
    Experimental Transmission of Toxoplasma gondii (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 961-962 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Six mice were each given a subcutaneous injection of 50 cysts of the Beverley strain of Toxoplasma. After three months, the mice were killed and, when the brains were examined, they were found to be infected with large numbers of toxoplasmic cysts. After examination, the brains, together with the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/206961a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The ultrastructural development of the macrogamete ofEimeria stiedai (1980)
    Springer
    Protoplasma 104 (1980), S. 33-41 
    Details
    ISSN: 1615-6102
    Keywords: Development ; Eimeria stiedai ; Macrogamete ; Ultrastructural changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The development of the macrogamete ofEimeria. stiedai in the epithelial cells of the bile ducts of rabbits was studied by electron microscopy. A macrogamete was first identified by the presence of a large central nucleus with prominent nucleolus, and subsequently by the appearance of wall forming bodies. The macrogamete was limited by an outer single membrane under which there were remnants of a second membrane. The parasitophorous vacuole, in which the macrogamete was located, was often narrow and it contained no intravacuolar-tubules or -folds. As macrogametogony proceeded wall forming bodies of Type I and II, canaliculi, electron pale spaces (lipid) and polysaccharide granules increased in number. Granular endoplasmic reticulum, mitochondria and Golgi bodies were present throughout.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01279366
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  • 3
    Electronic Resource
    Electronic Resource
    An ultrastructural study of the early development and tissue cyst formation of Toxoplasma gondii in the brains of mice (1987)
    Springer
    Parasitology research 73 (1987), S. 483-491 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The ultrastructural features of the early development and tissue cyst formation of Toxoplasma gondii were examined in the brains of mice at various intervals from 7 days to 22 months post inoculation (PI). At 11 days PI toxoplasms, with the ultrastructural features of the proliferative (endozoite) form, were identified undergoing multiplication within both inflammatory and neural cells. Early tissue cyst formation was also observed, predominantly within neurons. By 21 days PI the proliferative forms had disappeared and only developing tissue cysts containing densely packed cystozoites were present. The proportion of dividing cystozoites decreased with increasing size and age of the cysts. The wall of the tissue cyst developed as an adaptation of the lining of the parasitophorous vacuole. In the majority of older cysts, numerous tubular structures were present beneath the cyst wall. All the cysts observed were retained within intact host cells. The only morphological change with increasing age was that a proportion of the older cysts contained loosely packed cystozoites in an electron lucent ground substance. There was no evidence of any degenerative changes within the cystozoites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00535321
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  • 4
    Electronic Resource
    Electronic Resource
    Tissue cyst rupture in mice chronically infected withToxoplasma gondii (1989)
    Springer
    Parasitology research 75 (1989), S. 599-603 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The incidence and effect of tissue cyst rupture in the brains of mice chronically infected withToxoplasma gondii was studied by immunocytochemistry and electron microscopy. Cyst rupture was extremely rare (2 of 750 tissue cysts) irrespective of the interval post-infection. The event was associated with a rapid cell-mediated immune response, giving rise to microglial or inflammatory nodules. Macrophages were observed to engulf and degrade the cystozoites and cyst debris. Initially, the nodules contained large amounts of immunologically reactive material, but this was degraded with the majority (94%) of lesions containing no recognizable parasites orToxoplasma antigens. There was little evidence of parasite multiplication or new cyst formation associated with cyst rupture. This study shows that although intermittent cyst rupture occurs, in immunocompetent individuals the immune response limits the potential damage from the release of large numbers of infective organisms to small microglial/inflammatory nodules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00930955
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  • 5
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    Experimental Transmission of Toxoplasma gondii (1965)
    Springer Nature
    Details
    Publication Date: 1965-05-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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