Publication Date:
2014-09-13
Description:
Article The transduction of mechanical forces into signals that alter cardiac contractility is important for heart function. Here the authors show that integrin-linked kinase acts as a mechanosensor in cardiomyocytes, and affects cardiac contractility by regulating SERCA-2a and phospholamban. Nature Communications doi: 10.1038/ncomms5533 Authors: Alexandra Traister, Mark Li, Shabana Aafaqi, Mingliang Lu, Sara Arab, Milica Radisic, Gil Gross, Fiorella Guido, John Sherret, Subodh Verma, Cameron Slorach, Luc Mertens, Wei Hui, Anna Roy, Paul Delgado-Olguín, Gregory Hannigan, Jason T. Maynes, John G. Coles
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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