Publication Date:
2017-08-04
Description:
The compounds [(η 6 - p -cymene)RuCl 2 (4-nitroaniline)] and [(η 6 - p -cymene)RuCl 2 (2-halogen-4-nitroaniline)] were synthesized and characterized by various means. The [(η 6 - p -cymene)RuCl 2 (4-nitroaniline)] and [(η 6 - p -cymene)RuCl 2 (2-fluoro-4-nitroaniline)] compounds were determined by X-ray diffraction, appearing in a distorted piano-stool type of arrangement with similar bond lengths and angles around the ruthenium. The compounds exhibited moderate to strong in vitro cytotoxicity against A549 and MCF-7 human cancer cells. Substitution of heavy halogen atom on the ortho position of para -nitroaniline weakened the cytotoxicity against both of MCF-7 and A549, except the cases of fluorine substitution for hydrogen atom regarding A549 and bromine substitution for chlorine atom regarding MCF-7, which showed minor deviation.
Print ISSN:
0044-2313
Electronic ISSN:
1521-3749
Topics:
Chemistry and Pharmacology
Permalink