ISSN:
1072-8368
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Medicine
Notes:
[Auszug] Mammalian carboxylesterases cleave the anticancer prodrug CPT-11 (Irinotecan) into SN-38, a potent topoisomerase I poison, and 4-piperidino-piperidine (4PP). We present the 2.5 Å crystal structure of rabbit liver carboxylesterase (rCE), the most efficient enzyme known to activate CPT-11 in ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/nsb790
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