ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Retention
;
Crown ethers
;
Actinomycin D
;
Metal cation complexation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Retention of crown ethers in reverse-phase HPLC has been determined by their bonding ability with cations present in the eluent. The dependence of retention of crown ethers on cation concentration exhibits an inflection and makes it possible to calculate stability constant for the crown ether-cation complex. It is shown that in 75% MeOH retention of antitumor antibiotic, actinomycin D, depends on [Na+] and not on [K+] at concentrations of K+ from 5×10−7 to 10−1 mol l−1. Hence, actinomycin D may be classified as an ionophore-antibiotic.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02276129
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