ISSN:
1476-5535
Keywords:
Dopamine receptor
;
Agonist and antagonist
;
Ligand
;
Dihydroxy acetanilide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary A natural product, Sch 42029, isolated from the fermentation of anActinoplanes sp. (SCC 1971) was found to displace Sch 23390 from the dopamine-1 (D1) receptor. The compound was isolated from the fermentation broth by adsorption of the filtrate on XAD-16 resin, elution with water-methanol, followed by purification by gel-permeation chromatography and HPLC. Using spectroscopic analysis, the structure was determined to be 2,5-dihydroxy acetanilide. The pure compound displaced Sch 23390, a D1-selective ligand, at aK i of 1.6 μm and spiperone, a D2-selective ligand, at aK i of 200 μm.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01575852
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