Publication Date:
2018-10-16
Description:
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models, Published online: 15 October 2018; doi:10.1038/s41467-018-06675-3 Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that underlies the memory deficits, and can be pharmacologically rescued.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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