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  • 1
    Electronic Resource
    Electronic Resource
    Autoradiographic localization of platelet-activating factor (PAF) binding sites in the rabbit endometrium during the peri-implantation period (1991)
    Springer
    Cell & tissue research 265 (1991), S. 231-241 
    Details
    ISSN: 1432-0878
    Keywords: Platelet-activating factor ; Receptors ; Endometrium ; Implantation ; Autoradiography ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This communication describes the use of in-vivo and in-vitro autoradiography to map specific platelet-activating factor (PAF) receptors in the rabbit uterus. Specific [3H]PAF uptake was predominantly localized on epithelial, but not on stromal or myometrial cells. Very few silver grains were associated with the luminal epithelial cells in the uterus of the estrous rabbit, primarily because of the non-differentiated state of the epithelium. In the differentiated pregnant uterus, significantly more [3H]PAF was bound to the glandular epithelial cells, with the stromal cells binding consistently significantly less. The highest density of silver grains was observed at the implantation sites on day 7 of pregnancy. There was no apparent difference in [3H]PAF C18:0 uptake between the epithelial cells at the inter-implantation zone on day 7 and on day 6. Bound [3H]PAF was displaceable by lyso-PAF, U66985, CV3988, but not U66982, L652,731, SRI 63,441 or the inactive PAF isomer, oleoyl PAF. Bovine serum albumin (BSA) significantly inhibited tissue uptake of [3H]PAF C18:0. Intraluminally administered [3H]PAF C18:0 and intravenously injected [3H]methylcarbamyl-PAF, a non-metabolizable PAF analog, penetrated the implanted blastocyst and bound to the embryoblast. This event was reproducible in vitro with pre-implantation blastocysts from day-6 pregnant rabbits, which suggests that uterine-derived PAF may translocate into the blastocyst after attachment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398071
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  • 2
    Electronic Resource
    Electronic Resource
    Temporal and spatial expression of leukemia inhibitory factor in rabbit uterus during early pregnancy (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 38 (1994), S. 148-152 
    Details
    ISSN: 1040-452X
    Keywords: Leukemia inhibitory factor ; Rabbit ; Endometrium ; Blastocyst implantation ; Pregnancy ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to document the appearance of LIF in the rabbit uterus during early pregnancy and to determine whether changes just prior to implantation, similar to those in mice, occurred. LIF was localized in endometrial epithelium, myometrium, and endometrial glands. A low level of LIF was detected in the uterus of nonestrous and estrous females. LIF expression reached its highest level on day 5 of pregnancy and declined on days 6 and 7. By day 13 of pregnancy, little endometrial LIF was apparent. The expression of LIF on day 5 of pseudopregnancy was similar to that on day 5 of pregnancy. LIF expression was much higher at implantation sites than that at nonimplantation areas on day 7 of pregnancy. It is concluded that LIF may be important for the implantation of rabbit blastocysts. © 1994 Wiley-Liss, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080380205
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  • 3
    Electronic Resource
    Electronic Resource
    Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 42 (1995), S. 407-414 
    Details
    ISSN: 1040-452X
    Keywords: LIF ; LIF receptor ; gp 130 ; Mouse ; Implantation ; Pregnancy ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to investigate the changes of LIF protein, LIF receptor, and gp 130 in the mouse uterus during the early pregnancy. LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy. gp 130 was highest on days 3 and 4 of pregnancy. Both LIF receptor and gp 130 showed strong staining in the stroma of the day 5 uterus, at a time when LIF protein was low. The presence of LIF receptor and gp 130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor. The coexistence of a high level of LIF protein, LIF receptor, and gp 130 in the day 4 uterus is consistent with the previously observed high level of uterine LIF mRNA on the same day and the importance of LIF for the blastocyst implantation in mouse. © 1995 wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080420406
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of lloprost, a stable prostacyclin analog, PGE2 and PGF2α on rabbit blastocysts (1988)
    New York, NY : Wiley-Blackwell
    Gamete Research 20 (1988), S. 203-213 
    Details
    ISSN: 0148-7280
    Keywords: prostaglandin uptake ; water uptake ; blastocyst function ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The uptake of prostaglandins (PGs) into day-6 rabbit blastocysts was studied. Uptake of PGE2 and PGF2α was temperature sensitive and nonsaturable up to 1,000 nM external concentration. In contrast, uptake of Iloprost, a stable prostacyclin analog, was unaffected by temperature, and showed apparent saturation at 〉2 nM concentration. Individual blastocysts exposed to 0.2 μM radioinert prostaglandins for 1 hr did not swell significantly. Blastocyst concentration of PGF2α was 4.8 ± 2.1-fold higher than that of PGE2, which was 9.5 ± 2.4-fold greater than that of 6-keto-PGF1α (the stable metabolite of prostacyclin). Uptake of tritiated water was increased by exposure of blastocysts to 0.2 μM PGE2 or PGF2 or PGF2α, but not to Iloprost. Thus, imbibition of water does not cause blastocyst swelling at least during limited in vitro culture. It is concluded that prostacyclin is of less importance in blastocyst function than PGE2 or PGF2α.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120200210
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  • 5
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    Autoradiographic localization of platelet-activating factor (PAF) binding sites in the rabbit endometrium during the peri-implantation period (1991)
    Springer
    Details
    Publication Date: 1991-08-01
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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