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  • 1
    ISSN: 1474-8673
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Chemistry and Pharmacology , Medicine
    Notes: 1 This study evaluated the inhibitory action of apigenin-7-O-β-d-glucuronopyranoside (AGC), apigenin, and omeprazole on reflux oesophagitis and gastritis in rats. AGC was isolated from Clerodendron trichotomum leaves. 2 Oesophagitis and gastritis were induced by surgical procedure and the administration of indomethacin, respectively. The intraduodenal (i.d.) administration of AGC decreased the volume of gastric juice and increased the gastric pH compared with apigenin and omeprazole. The acid output was more inhibited by AGC in a dose-dependent manner than by apigenin and omeprazole. Compared with apigenin and omeprazole, AGC significantly decreased the size of gastric lesions, which were induced by exposure of the gastric mucosa to indomethacin. 3 Malondialdehyde (MDA) content, which is the end product of lipid peroxidation, was increased significantly after the induction of reflux oesophagitis. The MDA content was decreased by AGC (i.d. 3 mg kg−1), but not by either apigenin or omeprazole. This suggests that AGC has an antioxidative effect. In the oesophagitis group, the mucosal levels of glutathione (GSH) were significantly lower than that in the normal group. However, the GSH levels were preserved after administering the AGC, suggesting that AGC possesses scavenging activity. 4 In summary, AGC is more potent than apigenin and omeprazole at inhibiting reflux oesophagitis and gastritis and may therefore be a promising drug for their treatment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Thin Solid Films 79 (1981), S. 83-90 
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2014-10-02
    Description: It is known that magnetic perturbations can mitigate edge localized modes (ELMs) in experiments, for example, MAST [Kirk et al ., Nucl. Fusion 53 , 043007 (2013)]. One hypothesis is that the magnetic perturbations cause a three dimensional corrugation of the plasma and this corrugated plasma has different stability properties to peeling-ballooning modes compared to an axisymmetric plasma. It has been shown in an up-down symmetric plasma that magnetic perturbations in tokamaks will break the usual axisymmetry of the plasma causing three dimensional displacements [Chapman et al ., Plasma Phys. Controlled Fusion 54 , 105013 (2012)]. We produce a free boundary three-dimensional equilibrium of a lower single null MAST relevant plasma using VMEC [S. P. Hirshman and J. C. Whitson, Phys. Fluids 26 , 3553 (1983)]. The safety factor and pressure profiles used for the modelling are similar to those deduced from axisymmetric analysis of experimental data with ELMs. We focus on the effect of applying n  = 3 and n  = 6 magnetic perturbations using the resonant magnetic perturbation (RMP) coils. A midplane displacement of over ±1 cm is seen when the full current is applied. The current in the coils is scanned and a linear relationship between coil current and midplane displacement is found. The pressure gradient in real space in different toroidal locations is shown to change when RMPs are applied. This effect should be taken into account when diagnosing plasmas with RMPs applied. The helical Pfirsch-Schlüter currents which arise as a result of the assumption of nested flux surfaces are estimated for this equilibrium. The effect of this non-axisymmetric equilibrium on infinite n ballooning stability is investigated using COBRA [Sanchez et al ., J. Comput. Phys. 161 , 576–588 (2000)]. The infinite n ballooning stability is analysed for two reasons; it may give an indication of the effect of non-axisymmetry on finite n peeling-ballooning modes, responsible for ELMs; and infinite n ballooning modes are correlated to kinetic ballooning modes which are thought to limit the pressure gradient of the pedestal [Snyder et al ., Phys. Plasmas 16 , 056118 (2009)]. The ballooning mode growth rate gains a variation in toroidal angle. The equilibria with midplane displacements due to RMP coils have a higher ballooning mode growth rate than the axisymmetric case and the possible implications are discussed.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
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  • 4
    Publication Date: 1981-05-01
    Print ISSN: 0040-6090
    Electronic ISSN: 1879-2731
    Topics: Physics
    Published by Elsevier
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