ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Concentrated normal urines were investigated by an immuno-electrophoretic technique using specific antiserum directed against uromucoid (=Tamm andHorsfall's urinary mucoprotein). A single precipitation line was observed, which, however, presented two distinct maxima. The faster antigen appeared to be situated between albumin and α1-globulin, while the slower antigen seemed to be ana 2-globulin. Both antigens were immunologically identical with uromucoid, although the latter had been eliminated by salt precipitation from the urines used in this experiment. The above findings can best be explained by assuming the occurrence of a polymer series of uromucoid, of which the lower members would be soluble in 0.58M NaCl, while the higher terms would representTamm andHorsfall's mucoproteinsensu stricto. It is suggested that cylindroids and nubecula represent visible forms of uromucoid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02158120
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