ISSN:
0021-9304
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
A system has been devised to test the potential denaturing effects of large, surfaces of various plastics on the proteins in human plasma. This system permits a blood sample to be drawn, so that from the time it leaves the vein it contacts only the material under study; the plasma is separable in situ, and no air or gas interface is present during the test.Although silicone rubber proved to be relatively inert to the numerous plasma protein parameters investigated, silicone rubber that had been heparinized by treatment with the quaternary ammonium salt TDMAC caused a severe denaturation of the plasma lipoproteins exposed to it. On the other hand, silicone rubber heparinized via treatment of the filler silica particles did not show these effects. Ethylene-vinyl acetate and acrylamide gel also were found to be inert to the proteins in plasma, while several other plastics revealed only minor alterations. Control plasma samples maintained at 37°C were surprisingly stable under the experimental conditions used.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jbm.820040406
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