Publication Date:
1985-04-26
Description:
A 37-kilodalton protein is synthesized at higher rates in the peripheral and central nervous system of newborn rats than in adult animals. As a specific response to denervation, the synthesis of the 37-kilodalton protein is increased in the mature peripheral and central nervous system; however, this protein accumulates only in the peripheral nervous system. The differences in accumulation of the protein correlate with the apparent differences in the ability of peripheral and central axons to regenerate. The synthesis of the 37-kilodalton protein is inhibited when proper innervation or reinnervation is established.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, H W -- Gebicke-Harter, P J -- Hangen, D H -- Shooter, E M -- NS 04270/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Apr 26;228(4698):499-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3983637" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Animals, Newborn/physiology
;
Axons/physiology
;
Brain/physiology
;
Central Nervous System/metabolism/*physiology
;
Molecular Weight
;
*Nerve Regeneration
;
Nerve Tissue Proteins/*biosynthesis
;
Optic Nerve/physiology
;
Peripheral Nerves/metabolism/*physiology
;
Photofluorography
;
Rats
;
Rats, Inbred Strains
;
Sciatic Nerve/physiology
;
Spinal Cord/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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