Publication Date:
1988-03-18
Description:
In the anterior pituitary gland, there are five phenotypically distinct cell types, including cells that produce either prolactin (lactotrophs) or growth hormone (somatotrophs). Multiple, related cis-active elements that exhibit synergistic interactions appear to be the critical determinants of the transcriptional activation of the rat prolactin and growth hormone genes. A common positive tissue-specific transcription factor, referred to as Pit-1, appears to bind to all the cell-specific elements in each gene and to be required for the activation of both the prolactin and growth hormone genes. The data suggest that, in the course of development, a single tissue-specific factor activates sets of genes that ultimately exhibit restricted cell-specific expression and define cellular phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, C -- Albert, V R -- Elsholtz, H P -- Lu, L I -- Rosenfeld, M G -- New York, N.Y. -- Science. 1988 Mar 18;239(4846):1400-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine 92093.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2831625" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Avian Sarcoma Viruses/genetics
;
Binding, Competitive
;
Cell Line
;
DNA, Recombinant
;
Enhancer Elements, Genetic
;
*Gene Expression Regulation
;
Growth Hormone/*genetics
;
Phenotype
;
Photochemistry
;
Pituitary Gland, Anterior/metabolism
;
Prolactin/*genetics
;
Promoter Regions, Genetic
;
Rats
;
Regulatory Sequences, Nucleic Acid
;
Transcription Factors/*physiology
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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