ISSN:
1573-8221
Keywords:
epilepsy
;
hippocampus
;
kynurenins
;
serotonin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Experiments on frogs with an epileptogenic focus produced by injection of 1000 units penicillin (0.4 μl) into the primordial hippocampus showed that preliminary injection of two kynurenins — quinolinic acid (QA, 0.1 μg) and kynurenin itself (K, 1 μg) — into the region of the focus or their injection into an already functioning epileptogenic focus led to an increase in the frequency of interictal epileptiform discharges and of electrographic correlates of fits on the EEG. Anthranilic acid (AA, 5 μg) had no effect on activity of the focus whereas serotonin (S, 1 μg) and 5-methoxytryptamine (1 μg) substantially depressed it. The provoking action of the kynurenins on epileptically predisposed brain neurons, it is suggested, may play an important role in the pathogenesis of epilepsy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00833971
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