Publication Date:
2004-11-16
Description:
Anemia of chronic disease (ACD) is a hypoproliferative anemia typically associated with chronic infection, inflammation and cancer. High circulating levels of pro-inflammatory cytokines cause ACD, through impaired iron utilization and blunted EPO response. It has been proposed that elevated pro-inflammatory cytokines found with aging may be responsible for unexplained anemia (UA) commonly seen in older adults. Objective: Determine the relationship between several inflammatory markers, circulating EPO and hemoglobin (Hb) in elderly patients (pts). Methods: We used data from a large (n=1453) cross-sectional study conducted in Chianti, Italy; 1235 elderly pts were randomly selected (538 men; 697 women) and provided blood for measurement of Hb, serum EPO, CRP, circulating cytokines (IL-6, IL-1, IL-1ra, IL-1b, TNF-a), ferritin, iron, folate and B12. Anemia was defined by WHO criteria (women, 1.75pg/mL; IL-1b, 〉0.12pg/mL; TNF-a, 〉2.52pg/mL. ACD was defined as ferritin 〈 15ng/mL, sTfr index
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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