Publication Date:
2021-03-21
Description:
Background After resection of colorectal cancer liver metastases (CRLM) two main histopathological growth patterns can be observed; a desmoplastic and a non-desmoplastic subtype. The desmoplastic subtype has been associated with superior survival. These findings require external validation. Methods An international multicenter retrospective cohort study was conducted in patients treated surgically for CRLM at three tertiary hospitals in the US and the Netherlands. Determination of histopathological growth patterns was performed on hematoxylin & eosin stained sections of resected CRLM according to international guidelines. Patients displaying a desmoplastic histopathological phenotype (only desmoplastic growth observed) were compared to patients with a non-desmoplastic phenotype (any non-desmoplastic growth observed). Cut-off analyses on the extent of non-desmoplastic growth were performed. Overall (OS) and disease-free (DFS) survival were estimated using Kaplan-Meier and multivariable Cox analysis. All statistical tests were 2-sided. Results In total 780 patients were eligible. A desmoplastic phenotype was observed in 19.1% and was associated with microsatellite instability (14.6% versus 3.6%, p = .01). Desmoplastic patients had superior 5-year OS (73.4% [95% CI = 64.1–84.0] versus 44.2% [95% CI = 38.9–50.2], p
Electronic ISSN:
2515-5091
Topics:
Chemistry and Pharmacology
,
Medicine
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