ISSN:
0899-0042
Keywords:
milacemide
;
metabolites
;
enantiomers
;
hydroxylation
;
cytochrome P-450
;
γ-valerolactone
;
enzymic kinetic resolution
;
1H-NMR shift reagent
;
(-)-(1S)-camphanyl diastereomeric derivatives
;
solid solution
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Both (R)- and (S)-4-hydroxypentylaminoacetamide have been synthesized by reductive amination of glycinamide on the γ-valerolactols corresponding to (R)- and (S)-γ-valerolactone, respectively. These enantiomeric lactones were readily obtained in high enantiomeric excess (ee) by enzymic porcine pancreatic lipase (PPL) kinetic resolution of rac-methyl γ-hydroxyvalerate. © 1992 Wiley-Liss, Inc.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530040505
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