Publication Date:
2014-07-16
Description:
Imidoyl chlorides, generated from isocyanides and acyl chlorides, react with trialkyl phosphites, in a Perkow -type reaction, to afford 3-(alkylimino)-2-[(dialkyloxyphosphoryl)oxy]acrylates, which undergo a smooth reaction with tosylmethyl isocyanide (TsMIC) to furnish 4-(alkylamino)-3-[(dialkyloxyphosphoryl)oxy]-5-[(4-methylphenyl)sulfonyl]-3 H -pyrrole-3-carboxylates in moderate-to-good yields.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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