Publication Date:
2018-12-18
Description:
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis, Published online: 17 December 2018; doi:10.1038/s41467-018-07785-8 It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and lesion sizes in MS lesions.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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