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  • 1
    Electronic Resource
    Electronic Resource
    Distribution of Ultrabithorax proteins in mutants of Drosophila bithorax complex and its transregulatory genes (1985)
    [s.l.] : Nature Publishing Group
    Nature 318 (1985), S. 569-571 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Ubx products were visualized by immunofluorescence using a monoclonal antibody specific for the protein products of the common 5' exon of the Ubx transcription unit4. The distribution of the Ubx proteins was studied in imaginai disks of mature larvae. Positive label only indicates the presence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/318569a0
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic and developmental analyses of chaetae pattern formation in Drosophila tergites (1991)
    Springer
    Development genes and evolution 200 (1991), S. 132-142 
    Details
    ISSN: 1432-041X
    Keywords: Pattern formation ; Neurogenic genes ; Achaete-scute gene complex ; Cell interations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The role of the achaete-scute complex and extramacrochaetae, Notch, Delta, Enhancer of split and Hairless genes in chaeta patterning in Drosophila tergites was studied in genetic mosaics and in mutant combinations. The mutant phenotypes of different alleles of each gene can be ordered in characteristic topographical seriations. These seriations are related to the pattern of proliferation of histoblasts and the time of singularization of sensory organ mother cells from surrounding epidermal cells. Genetic mosaics of lethal alleles show that these genes are fundamentally involved in this singularization and subsequent differentiation. The study of mutant combinations of alleles of these genes reveals specific relationships of epistasis and synergism between them. The results suggest that spatial and temporal variations in achaete-scute complex functional products in cells, modulated by the activity of other genes involved in signal transduction, define the patterned differentiation of sensory organs in tergites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190232
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  • 3
    Electronic Resource
    Electronic Resource
    Patterns of protein synthesis in the imaginal discs of Drosophila melanogaster: a comparison between different discs and stages (1993)
    Springer
    Development genes and evolution 203 (1993), S. 131-139 
    Details
    ISSN: 1432-041X
    Keywords: Wing imaginal discs ; Growth ; Metamorphosis ; Protein database ; two-dimensional gel electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract High-resolution two dimensional gel electrophoresis has been used to study the patterns of protein synthesis in imaginal discs of Drosophila melanogaster. In this paper we first compare the patterns of protein synthesis in wing, haltere, leg 1, leg 2, leg 3 and eye antenna imaginal discs of late third instar larvae. We have detected only quantitative changes: differences in 17 proteins among the different imaginal discs. In addition, we have analysed the variations in pattern of proteins in the wing disc of the last larval stage and early pupae as well as in wing discs cultured in vivo for 6 days. Variations in these patterns affect more than 20% of the proteins and involve both qualitative and quantitative changes. Some of the changes may correspond to protein phosphorylation. Correlations of these changes between discs and through development are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365052
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  • 4
    Electronic Resource
    Electronic Resource
    Analyse der physiologischen Bedingungen des Vermehrungswachstums männlicher Keimzellen von Drosophila melanogaster (1964)
    Springer
    Development genes and evolution 155 (1964), S. 611-631 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 48 h old testis were implanted into different adult hosts. In virgin females the germ cell multiplication is lower than in both mated females or in males. However in all host types the differentiation into spermatids beginns at the same time as in situ. The role of the different adult host glands in male germ cell development was investigated. Through inactivation of such glands in mated females or implantation of extra glands in virgin hosts was demonstrated, that not the adult Corpus allatum but the Median Neurosecretory Brain Cells (MNBC) are responsable for this germ cell multiplication. Adult host provided with larval Ring gland or pupal host accelerate the germ cell differentiation but not the germ cell multiplication of implanted testis. This acceleration would be much higher if the normal development of the germ cells in adult hosts were due to rests of pupal hormons in this milieu. The nutritive conditions of the host play a very important role in germ cell multiplication. The testis implanted in castrated females or females injected with casein hydrolisate show a higher number of developing germ cells. The MNBC controll the protein metabolism (assimilation) but are only indirectly responsable for the germ cell multiplication; the multiplication is a consequence of the autonomous protein synthesis of the germ cells themself. The growth of other imaginal discs in adult hosts are discussed in the light of these results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572818
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  • 5
    Electronic Resource
    Electronic Resource
    Histotypic reaggregation of dissociated imaginal disc cells ofDrosophila melanogaster culturedin vivo (1967)
    Springer
    Development genes and evolution 158 (1967), S. 212-217 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Cell dissociates of wing and leg imaginal discs perform, culturedin vivo, disc specific morphogenetic movements leading to their aggregation into layers and vesicles. These histological patterns correspond directly with the final cuticular patterns which appear after metamorphosis of the same implants. The reaggregation into layers is achieved before the entry of the blastems into metamorphosis, and reflects the existence of traits of differentiation in the isolated imaginal disc cells. The bearing of selective affinity and reaggregation on cell differentiation of imaginal discs cells is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00573398
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  • 6
    Electronic Resource
    Electronic Resource
    Beziehungen zwischen Vermehrungswachstum und Differenzierung von männlichen Keimzellen von Drosophila melanogaster (1964)
    Springer
    Development genes and evolution 155 (1964), S. 594-610 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A count-chamber like methodes enables us to estimate the number of cysts corresponding to each developmental stage of the spermatogenesis. The multiplication of the germ cells depends upon the physiological conditions of the host: it is stopped in isolated larval abdomina, and is low in larvae of a crowded culture where pupation is delayed. In implants of 48 h old testis in. virgin adult females the multiplication rate is lower than in males and in mated females; it is as high as in situ in castrated females or in pupal hosts. The time required for the oldest cysts with spermatocytes to enter the meiotic divisions is with one exception for all these experiments the same as in situ; only in pupal hosts it will be accelerated. The subsequent spermatid differentiation in sperm also takes the same time as in situ. Thereby the premeiotic growth and postmeiotic differentiation is as efficient in all tested milieus as in situ, even when the hosts have not attained or already bypassed the metamorphosis. This autonomy is also valid for germ cells under insufficient multiplying conditions, provided that the spermatocytes have reached a certain stage in the premeiotic growth. When the first cysts reach the postmeiotic stages the further multiplication of cysts is stopped. This regulative mechanism is attributed to a specific inhibition operated by the spermatids. The autonomy of the spermatocyte differentiation and the unified behaviour of all the cells within a cyst are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572817
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  • 7
    Electronic Resource
    Electronic Resource
    Developmental analysis of two wing scalloping mutantsct 6 andBx J ofDrosophila melanogaster (1975)
    Springer
    Development genes and evolution 178 (1975), S. 233-245 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The mutantscut 6 (ct6) andBeadex of Jollos (Bx J) show nicks in the wing margins as well as other malformations in different regions of the body. Clonal analysis of the wing disk's development in these mutants indicates that massive cell loss occurs during the third larval instar. Morphogenetic mosaics, originating from mitotic recombination, reveal a non-autonomous behaviour of both mutant and wild-type cells. X-rays applied during the third larval instar produce phenocopies of these mutants. A clonal and a genetic analysis of these phenocopies has been carried out. The hypothesis that scalloping mutants such asct 6, BxJ and others, as well as X-rays, affect properties of cellular interaction, such as cell adhesivity or cohesion, is discussed. Morphogenetic mosaics in the wing margin suggest that the differentiation of the marginal cuticular elements requires the interaction of the cells of the ventral and dorsal surfaces of the wing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848431
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  • 8
    Electronic Resource
    Electronic Resource
    The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning (1988)
    Springer
    Development genes and evolution 197 (1988), S. 424-434 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Ultrabithorax ; Development ; Regulation ; Protein distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Most viable alleles of homeotic genes cause partial transformations within given lineages in a topographically specific fashion. We study this phenomenon as a way to understand the normal mechanisms involved in the spatial regulation of homeotic gene expression. To this end we have investigated the distribution of Ultrabithorax (Ubx) proteins in imaginai discs mutant for hypomorphic and neomorphic alleles of Ubx and alleles of trans-acting genes. We find that the morphological discontinuities observed in the adult transformations are caused by corresponding new patterns of the Ubx proteins in the imaginai anlagen. These novel patterns of Ubx proteins are understood as a consequence of a process of reinforcement-extinction of Ubx expression. The evidence suggesting that this process results from a positive feed-back loop and cell-cell interactions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398994
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  • 9
    Electronic Resource
    Electronic Resource
    Etxtramacrochaetae, a trans-acting gene of the achaete-scute complex of drosophila involved in cell communication (1988)
    Springer
    Development genes and evolution 197 (1988), S. 518-518 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00385687
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  • 10
    Electronic Resource
    Electronic Resource
    Function of trans-acting genes of theachaete-scute complex in sensory organ patterning in the mesonotum ofDrosophila (1991)
    Springer
    Development genes and evolution 200 (1991), S. 64-76 
    Details
    ISSN: 1432-041X
    Keywords: Achaete-scute gene complex ; Cell-cell interactions ; Cell differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Cell-cell interactions play a fundamental role in the differentiation of nervous elements in constant patterns, both during embryogenesis and imaginal development. In this paper we analyse the role of genes of theachaete-scute andEnhancer of split complexes, plus the genesextramacrochaetae, Notch, Delta, andHairless in the patterning of sensory elements in the mesonotum ofDrosophila. The phenotypes of different alleles of these genes, including lethals in genetic mosaics, reveal their participation in two processes, the singling out from epidermal cells of sensory organ mother cells and their subsequent differentiation. Studies of allelic combinations of different genes lead to a model of the genetic interactions involved in the processes of pattern formation. In this model, theachaete-scute complex plays a central role, determining sensory organ mother cells and preventing neighbouring cells from following the same developmental pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637186
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