Publication Date:
2012-08-31
Description:
Calorie restriction (CR), a reduction of 10-40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes. Our findings contrast with an ongoing study at the Wisconsin National Primate Research Center (WNPRC), which reported improved survival associated with 30% CR initiated in adult rhesus monkeys (7-14 years) and a preliminary report with a small number of CR monkeys. Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies. The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832985/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832985/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mattison, Julie A -- Roth, George S -- Beasley, T Mark -- Tilmont, Edward M -- Handy, April M -- Herbert, Richard L -- Longo, Dan L -- Allison, David B -- Young, Jennifer E -- Bryant, Mark -- Barnard, Dennis -- Ward, Walter F -- Qi, Wenbo -- Ingram, Donald K -- de Cabo, Rafael -- ZIA AG000371-08/Intramural NIH HHS/ -- England -- Nature. 2012 Sep 13;489(7415):318-21. doi: 10.1038/nature11432.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA. mattisonj@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22932268" target="_blank"〉PubMed〈/a〉
Keywords:
Age of Onset
;
Aging/*physiology
;
Animals
;
Blood Glucose/analysis
;
*Caloric Restriction
;
Cardiovascular Diseases/blood
;
Cholesterol/blood
;
Female
;
*Health
;
Humans
;
Incidence
;
Kaplan-Meier Estimate
;
Longevity/*physiology
;
Macaca mulatta
;
Male
;
Models, Animal
;
Monkey Diseases/blood
;
*National Institute on Aging (U.S.)
;
Neoplasms/blood
;
Survival Rate
;
Triglycerides/blood
;
Uncertainty
;
United States
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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