Publication Date:
1980-06-06
Description:
Cupric ion, a thiol oxidant, caused naloxone-reversible analgesia when injected intracerebroventricularly in mice; its potency was close to that of morphine. Dithiothreitol, a thiol reductant, reversed the analgesia induced by cupric ion and antagonized analgesia induced by morphine. Oxidized dithiothreitol had no effect. These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marzullo, G -- Hine, B -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246583" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*physiology
;
Copper/antagonists & inhibitors/*pharmacology
;
Dithiothreitol/pharmacology
;
Male
;
Mice
;
Naloxone/pharmacology
;
Oxidation-Reduction
;
Pain/*physiopathology
;
Rats
;
Receptors, Opioid/drug effects/*physiology
;
Sulfhydryl Compounds/pharmacology
;
Zinc/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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