Publication Date:
1980-07-11
Description:
During viral development bacteriophage T4 modifies the valyl-transfer RNA synthetase of its host Escherichia coli, but the function of the modification has remained elusive. A strain of Escherichia coli has now been identified which is nonpermissive for wild-type bacteriophage T4, but permissive for bacteriophage mutants impaired in the modification reaction. A comparison with other bacteria suggests that nonpermissiveness is due to synthesis of a thermolabile valyl-transfer RNA synthetase and relaxed control of RNA accumulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marchin, G L -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):294-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6992274" target="_blank"〉PubMed〈/a〉
Keywords:
Escherichia coli/*genetics
;
*Genes, Viral
;
*Mutation
;
Species Specificity
;
T-Phages/*genetics
;
Viral Plaque Assay
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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