Publication Date:
1982-01-08
Description:
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lentz, T L -- Burrage, T G -- Smith, A L -- Crick, J -- Tignor, G H -- AI 11132/AI/NIAID NIH HHS/ -- AI 12541/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053569" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/metabolism
;
Acetylcholinesterase/metabolism
;
Animals
;
Binding, Competitive
;
Bungarotoxins/metabolism
;
Cells, Cultured
;
Chick Embryo
;
Diaphragm
;
Mice
;
Microscopy, Electron
;
Neuromuscular Junction/*metabolism
;
Rabies virus/*metabolism
;
Receptors, Cholinergic/*metabolism
;
Receptors, Virus/*metabolism
;
Tubocurarine/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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