Publication Date:
1993-10-29
Description:
The Spermann organizer induces neural tissue from dorsal ectoderm and dorsalizes lateral and ventral mesoderm in Xenopus. The secreted factor noggin, which is expressed in the organizer, can mimic the dorsalizing signal of the organizer. Data are presented showing that noggin directly induces neural tissue, that it induces neural tissue in the absence of dorsal mesoderm, and that it acts at the appropriate stage to be an endogenous neural inducing signal. Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamb, T M -- Knecht, A K -- Smith, W C -- Stachel, S E -- Economides, A N -- Stahl, N -- Yancopolous, G D -- Harland, R M -- New York, N.Y. -- Science. 1993 Oct 29;262(5134):713-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8235591" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blastocyst/metabolism
;
CHO Cells
;
Carrier Proteins
;
Cricetinae
;
Embryonic Induction/*physiology
;
Gastrula/metabolism
;
Humans
;
Mesoderm/metabolism
;
Nervous System/*embryology
;
Proteins/*physiology
;
RNA, Messenger/metabolism
;
Recombinant Proteins
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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