Publication Date:
1996-07-12
Description:
An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cockett, N E -- Jackson, S P -- Shay, T L -- Farnir, F -- Berghmans, S -- Snowder, G D -- Nielsen, D M -- Georges, M -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):236-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322-4700, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662506" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosome Mapping
;
Crosses, Genetic
;
Female
;
*Genes, Dominant
;
*Genomic Imprinting
;
Genotype
;
Heterozygote
;
Lod Score
;
Male
;
Models, Genetic
;
Muscle, Skeletal/*anatomy & histology
;
Mutation
;
Phenotype
;
Sheep/*anatomy & histology/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
