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  • 1
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    Liquid-gas phase transition in hypernuclei (2015)
    American Physical Society (APS)
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    Publication Date: 2015-05-07
    Description: Author(s): S. Mallik and G. Chaudhuri The fragmentation of excited hypernuclear systems formed in heavy ion collisions has been described by the canonical thermodynamical model extended to three-component systems. The multiplicity distribution of the fragments has been analyzed in detail and it has been observed that the hyperons tend t... [Phys. Rev. C 91, 054603] Published Wed May 06, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Hybrid model for studying nuclear multifragmentation around the Fermi energy domain: The case of central collisions of Xe on Sn (2015)
    American Physical Society (APS)
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    Publication Date: 2015-04-21
    Description: Author(s): S. Mallik, G. Chaudhuri, and S. Das Gupta Experimental data for central collisions of 129 Xe on 119 Sn at beam energies of (a) 32, (b) 39, (c) 45, and (d) 50 MeV/nucleon are compared with results calculated using a hybrid model. We use a transport model (BUU) to obtain the excitation energy per nucleon in the center of mass of the multifragme... [Phys. Rev. C 91, 044614] Published Mon Apr 20, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 3
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    Event simulations in a transport model for intermediate energy heavy ion collisions: Applications to multiplicity distributions (2015)
    American Physical Society (APS)
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    Publication Date: 2015-03-27
    Description: Author(s): S. Mallik, S. Das Gupta, and G. Chaudhuri We perform transport model calculations for central collisions of mass 120 on mass 120 at laboratory beam energy in the range 20 MeV/nucleon to 200 MeV/nucleon. A simplified yet accurate method allows calculation of fluctuations in systems much larger than what was considered feasible in a well-know... [Phys. Rev. C 91, 034616] Published Thu Mar 26, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Finite-size effects on the phase diagram of the thermodynamical cluster model (2015)
    American Physical Society (APS)
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    Publication Date: 2015-12-09
    Description: Author(s): S. Mallik, F. Gulminelli, and G. Chaudhuri The thermodynamical cluster model is known to present a first-order liquid-gas phase transition in the idealized case of an uncharged, infinitely extended medium. However, in most practical applications of this model, the system is finite and charged. In this paper we study how the phase diagram is … [Phys. Rev. C 92, 064605] Published Mon Dec 07, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Improvements to a model of projectile fragmentation (2011)
    American Physical Society (APS)
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    Publication Date: 2011-11-18
    Description: Author(s): S. Mallik, G. Chaudhuri, and S. Das Gupta [Phys. Rev. C 84, 054612] Published Thu Nov 17, 2011
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 6
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    Model for projectile fragmentation: Case study for Ni on Ta and Be, and Xe on Al (2011)
    American Physical Society (APS)
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    Publication Date: 2011-04-19
    Description: Author(s): S. Mallik, G. Chaudhuri, and S. Das Gupta For projectile fragmentation, we work out details of a model whose origin can be traced back to the Bevalac era. The model positions itself between the phenomenological empirical parametrization of fragmentation cross sections (EPAX) and microscopic transport models like the heavy ion phase-space ex... [Phys. Rev. C 83, 044612] Published Mon Apr 18, 2011
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 7
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    Estimates for temperature in projectile-like fragments in geometric and transport models (2014)
    American Physical Society (APS)
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    Publication Date: 2014-04-26
    Description: Author(s): S. Mallik, S. Das Gupta, and G. Chaudhuri Projectile-like fragments emerging from heavy ion collision have an excitation energy which is often labeled by a temperature. This temperature was recently calculated using a geometric model. We expand the geometric model to include dynamic effects using a transport model. The calculated temperatur... [Phys. Rev. C 89, 044614] Published Fri Apr 25, 2014
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 8
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    Comparative evaluation of genotoxicity by micronucleus assay in the buccal mucosa over comet assay in peripheral blood in oral precancer and cancer patients (2014)
    Oxford University Press
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    Publication Date: 2014-08-23
    Description: Early detection and quantification of DNA damage in oral premalignancy or malignancy may help in management of the disease and improve survival rates. The comet assay has been successfully utilised to detect DNA damage in oral premalignant or malignancy. However, due to the invasive nature of collecting blood, it may be painful for many unwilling patients. This study compares the micronucleus (MN) assay in oral buccal mucosa cells with the comet assay in peripheral blood cells in a subset of oral habit-induced precancer and cancer patients. For this, MN assay of exfoliated epithelial cells was compared with comet assay of peripheral blood leucocytes among 260 participants, including those with oral lichen planus (OLP; n = 52), leukoplakia (LPK; n = 51), oral submucous fibrosis (OSF; n = 51), oral squamous cell carcinoma (OSCC; n = 54) and normal volunteers ( n = 52). Among the precancer groups, LPK patients showed significantly higher levels of DNA damage as reflected by both comet tail length ( P 〈 0.0001) and micronuclei (MNi) frequency ( P = 0.0009). The DNA damage pattern in precancer and cancer patients was OLP 〈 OSF 〈 LPK 〈 OSCC, and with respective oral habits, it was multiple habits 〉 cigarette + khaini 〉 cigarette smokers 〉 areca + khaini 〉 areca. There was no significant difference in the comet length and MNi frequency between males and females who had oral chewing habits. An overall significant correlation was observed between MNi frequency and comet tail length with r = 0.844 and P 〈 0.0001. Thus, the extent of DNA damage evaluation by the comet assay in peripheral blood cells is perfectly reflected by the MN assay on oral exfoliated epithelial cells, and MNi frequency can be used with the same effectiveness and greater efficiency in early detection of oral premalignant conditions.
    Print ISSN: 0267-8357
    Electronic ISSN: 1464-3804
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 9
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    Genome-Wide DNA Methylation Patterns in Wild Samples of Two Morphotypes of Threespine Stickleback (Gasterosteus aculeatus) (2015)
    Oxford University Press
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    Publication Date: 2015-04-01
    Description: Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development. To examine whether DNA methylation patterns are potentially associated with naturally occurring phenotypic differences, we examined genome-wide DNA methylation within Gasterosteus aculeatus , using reduced representation bisulfite sequencing. First, we identified highly methylated regions of the stickleback genome, finding such regions to be located predominantly within genes, and associated with genes functioning in metabolism and biosynthetic processes, cell adhesion, signaling pathways, and blood vessel development. Next, we identified putative differentially methylated regions (DMRs) of the genome between complete and low lateral plate morphs of G. aculeatus . We detected 77 DMRs that were mainly located in intergenic regions. Annotations of genes associated with these DMRs revealed potential functions in a number of known divergent adaptive phenotypes between G. aculeatus ecotypes, including cardiovascular development, growth, and neuromuscular development.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
    Published by Oxford University Press
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  • 10
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    Receptor-mediated drug delivery to macrophages in chemotherapy of leishmaniasis (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-05-12
    Description: Methotrexate coupled to maleylated bovine serum albumin was taken up efficiently through the "scavenger" receptors present on macrophages and led to selective killing of intracellular Leishmania mexicana amazonensis amastigotes in cultured hamster peritoneal macrophages. The drug conjugate was nearly 100 times as effective as free methotrexate in eliminating the intracellular parasites. Furthermore, in a model of experimental cutaneous leishmaniasis in hamsters, the drug conjugate brought about more than 90% reduction in the size of footpad lesions within 11 days. In contrast, the free drug at a similar concentration did not significantly affect lesion size. These studies demonstrate the potential of receptor-mediated drug delivery in the therapy of macrophage-associated diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukhopadhyay, A -- Chaudhuri, G -- Arora, S K -- Sehgal, S -- Basu, S K -- New York, N.Y. -- Science. 1989 May 12;244(4905):705-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Microbial Technology, Chandigarh, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2717947" target="_blank"〉PubMed〈/a〉
    Keywords: Albumins/*administration & dosage/metabolism ; Animals ; Cells, Cultured ; Cricetinae ; Female ; Kinetics ; Leishmania mexicana/*drug effects ; Leishmaniasis/*drug therapy ; Macrophages/metabolism/*parasitology ; Male ; *Membrane Proteins ; Mesocricetus ; Methotrexate/*administration & dosage/pharmacology/therapeutic use ; *Receptors, Immunologic/metabolism ; *Receptors, Lipoprotein ; Receptors, Scavenger ; Scavenger Receptors, Class B ; Serum Albumin, Bovine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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