Publication Date:
2015-03-15
Description:
Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578815/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578815/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gill, Shubhroz -- Le, Hiep D -- Melkani, Girish C -- Panda, Satchidananda -- DK091618/DK/NIDDK NIH HHS/ -- EY016807/EY/NEI NIH HHS/ -- NS066457/NS/NINDS NIH HHS/ -- P30 CA014195/CA/NCI NIH HHS/ -- P30 EY019005/EY/NEI NIH HHS/ -- R01 DK091618/DK/NIDDK NIH HHS/ -- R01 EY016807/EY/NEI NIH HHS/ -- R21 NS066457/NS/NINDS NIH HHS/ -- R21 RR032100/RR/NCRR NIH HHS/ -- RR032100/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2015 Mar 13;347(6227):1265-9. doi: 10.1126/science.1256682.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. Division of Biological Sciences, University of California San Diego, La Jolla, CA 92037, USA. ; Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. ; Departments of Biology and Molecular Biology, and Heart Institutes, San Diego State University, San Diego, CA 92182, USA. gmelkani@mail.sdsu.edu satchin@salk.edu. ; Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. gmelkani@mail.sdsu.edu satchin@salk.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25766238" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chaperonins/genetics/metabolism
;
*Circadian Clocks
;
Drosophila Proteins/genetics/metabolism
;
Drosophila melanogaster/genetics/*physiology
;
Electron Transport
;
Energy Intake
;
Feeding Behavior
;
Flight, Animal
;
Heart/physiology
;
Male
;
Metabolic Networks and Pathways
;
Mitochondria/metabolism
;
Myocardial Contraction
;
Sleep
;
Transcriptome
;
Weight Gain
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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