ISSN:
0170-2041
Keywords:
Fungal metabolites
;
Imides, open-chain
;
Fungicidal activity
;
Coniothyriomycin
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Biologically Active Metabolites of Fungi, I. - Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analoguos Open-Chain ImidesThe mixed open-chain imide N-(3-chloro-4-hydroxyphenyl-acetyl)fumarate (1), named coniothyriomycin, was isolated as metabolite of the fungus Coniothyrium. The natural product 1 and the analoguos imides 13-15 and 22-24 have been synthesized by base-catalyzed condensation of the imidates 12a-f with acid chlorides 6a-c or the mixed anhydride 21. The compounds 1 and 13-15 were shown to posess remarkable fungicidal and herbicidal activities in short-termed tests.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1992199201130
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