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  • 1
    Electronic Resource
    Electronic Resource
    Effect of heterogeneity on the lag time in one-dimensional diffusion (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 2278-2280 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A new general equation has been developed for the lag time for a dilute diffusant permeating through a one-dimensional membrane in which both diffusivity D and partition coefficient K are dependent on position. The lag time is given by tL=∫h0K(x)[∫x0 R(y)dy][∫hxR(y)dy] ×dx/ ∫h0R(x)dx, where h is the membrane thickness and R(x)=1/[D(x)K(x)]. Formulas derived from this equation include those for: lag time in the presence of an electrical potential gradient; lag time in a multilaminar periodic membrane; and an upper bound for lag time given by tL 〈(h2/ 4Deff), where Deff is the effective diffusivity as deduced from steady-state partitioning and permeability measurements. The lag time is shown to be independent of the direction of diffusion. A computational technique is presented in which the equation for tL is rearranged to a system of two differential equations, which are readily solvable by numerical integration, even when the system has discontinuities in D and K which would increase the difficulty of evaluating the double integral directly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.455070
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  • 2
    Electronic Resource
    Electronic Resource
    The business of developing antibacterials (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1521-1528 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1521
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  • 3
    Electronic Resource
    Electronic Resource
    Sandoz sues FDA over delay in first biogeneric approval (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1327-1328 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Officials at Sandoz, the generic branch of Novartis of Basel, filed a rare type of lawsuit with the US District Court on September 13. The company wants the court to force the US Food and Drug Administration (FDA) to rule on—preferably, approve—Omnitrope, its follow-on version of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1105-1327
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  • 4
    Electronic Resource
    Electronic Resource
    Beer giant blindsides Ventria's pharmacrop (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 636-636 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ventria Bioscience, a Sacramento, California-based biotech company scuttled plans in May for growing two of its genetically modified (GM) rice varieties in southern Missouri this year after being blindsided by beer maker Anheuser-Busch. Ventria officials describe the decision as a minor setback ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0605-636
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  • 5
    Electronic Resource
    Electronic Resource
    WHO resolves to send last smallpox stocks to a 1999 grave (1996)
    [s.l.] : Nature Publishing Group
    Nature medicine 2 (1996), S. 729-729 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Despite a muted debate in scientific circles, public health arguments in favor of destroying the remaining stocks of the deadly smallpox virus have finally won over officials of the World Health Organization (WHO) in Geneva, Switzerland. Late in May, WHO representatives from 190 countries approved ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0796-729
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  • 6
    Electronic Resource
    Electronic Resource
    Funding is tight for current efforts against emerging diseases… but new plans for surveillance are still being proposed (1996)
    [s.l.] : Nature Publishing Group
    Nature medicine 2 (1996), S. 733-733 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] From tuberculosis and AIDS to potato blight and bovine spongiform encephalopathy (BSE), infectious diseases kill not only people, but whole economies. The links between seemingly far-flung events involving pathogens and their hosts deserve a new kind of scrutiny if we are to deal effectively with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0796-733
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  • 7
    Electronic Resource
    Electronic Resource
    Industry blasts FDA disclosure rules (1995)
    [s.l.] : Nature Publishing Group
    Nature medicine 1 (1995), S. 862-863 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] With little or no fanfare, the US National Institutes of Health (NIH) and the US National Science Foundation (NSF) in mid-July issued final regulations on “Objectivity in Research,” requiring investigators to disclose financial interests that might “ directly and significantly ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0995-862b
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  • 8
    Electronic Resource
    Electronic Resource
    Reforms will ease patenting of biotechnology therapeutics (1995)
    [s.l.] : Nature Publishing Group
    Nature medicine 1 (1995), S. 104-104 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In a widely applauded move late last year, the US Commissioner of Patents and Trademarks, Bruce A. Lehman, announced new guidelines to streamline the review of biotechnology patent applications. Companies trying to obtain patent protection for new therapeutic products will no longer need to provide ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0295-104a
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  • 9
    Electronic Resource
    Electronic Resource
    Report recommends ban of US GM maize in Mexico (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 6-6 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A recent report on the possible effects of GM maize from the US on maize and other native plants in neighboring Mexico points to problematic regulatory and cultural gaps between the two countries, despite a recent move by Mexico to regulate GM crops. Moreover, recommendations in the report, which ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0105-6
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  • 10
    Electronic Resource
    Electronic Resource
    Vatican debates agbiotech (2004)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 4-5 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cardinal Renato Martino and other key Vatican officials seem poised to endorse the use of genetically modified (GM) crops. However, by the end of a seminar, “GMO: threat or hope,” convened by the Pontifical Council of Justice and Peace in Rome on November 10–11, he and several ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0104-4
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