Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉GBP1 targets 〈i〉Toxoplasma〈/i〉 and 〈i〉Salmonella〈/i〉 in macrophages and regulates host cell death. GBP1 promotes 〈i〉Toxoplasma 〈/i〉DNA detection by AIM2-ASC-caspase-8 leading to apoptosis and targeting of 〈i〉Salmonella〈/i〉 by caspase-4 leading to pyroptosis.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉IFN-induced GBP1 translocates to 〈i〉Toxoplasma gondii-〈/i〉 and 〈i〉Salmonella〈/i〉 Typhimurium-containing vacuoles in a lipidation and GTPase dependent manner.〈/p〉〈/li〉
〈li〉〈p〉GBP1 induces AIM2-, ASC- and caspase-8-dependent atypical apoptosis in 〈i〉Toxoplasma gondii〈/i〉-infected macrophages.〈/p〉〈/li〉
〈li〉〈p〉〈i〉Toxoplasma gondii〈/i〉 induces degradation of NLRP1, NLRP3, NLRC4 and pro-caspase-1, switching cell death type from pyroptosis to apoptosis.〈/p〉〈/li〉
〈li〉〈p〉GBP1 is essential for targeting of 〈i〉Salmonella〈/i〉 by caspase-4, its activation and increased pyroptosis.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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