ISSN:
1573-8221
Keywords:
mouse liver tumors
;
H-ras gene
;
codon 61 mutations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract PCR with subsequent sequencing showed that codon 61 of H-ras gene is presented by mutant variants in 7 of 13 liver tumors induced by neonatal injection of potent hepatocarcinogens o-aminoazotoluene or nitrosoethylurea in CBA mice, while in ICR mice tumors induced by these carcinogens carried only wild-type allele. Only mutant alleles of the studied codon were detected in 8 tumors induced with a weakly carcinogenous mutagen ethylmethansulfonate in ICR mice. In 7 of 15 cases these alleles were presented by two variants: AAA and CTA simultaneously (normal codon CAA) in CBA mice injected with o-aminoazotoluene and by CGA and CTA in ICR mice receiving ethylmethansulfonate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02433873
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