ISSN:
0935-6304
Keywords:
Capillary gas chromatography
;
Automatic static headspace
;
Residual solvents, residual reagent
;
X-ray contrast media
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A specific, sensitive, and simple method for the quantitation of residual methanol, 2-propanol, 2-butanol, 2-methoxy-1-ethanol, 1-chloro-3-methoxy-2-propanol, 3-chloro-2-methoxy-1-propanol, and 1,3-dimethoxy-2-propanol in two non-ionic X-ray contrast media, has been developed. The headspace of a 25 % w/V aqueous solution of contrast media, obtained at 90-110°C in 15 min, was injected onto a capillary column coated with cyanopropyl, phenyl, dimethylpolysiloxane polymer. The internal standards used were 2-pentanol and 3-methoxy-1-butanol. The limits of detection were below 5 μg/g. The repeatability of the method at 50 μg/g of each solvent was below 5 %; and at 100 μg/g of the methoxypropanol compounds and 2-methoxy-1-ethanol, below 10 % (RSD, N = 5).
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240130208
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