ISSN:
0075-4617
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Synthesis of Monomeric Cyclic Cystine Peptides, II. - Synthesis of the Sequence A 10-21 of Ovine Insulin as Monomeric, Cyclic, Asymmetric Cystine Peptide Derivative1)The completely protected cysteine peptide, Trt-Val-Cys(Trt)-Ser(But)-Leu-Tyr(But)-Gln-Leu-Glu(OBut)-Asn-Tyr(But)-Cys(Trt)-Asn-OBut (13), which corresponds to the amino acid series of sequence A 10-21 of the ovine insulin A-chain, was synthesized by fragment condensations. The product was then converted by treatment with iodine in methanol into the corresponding cystine peptide derivative 14 in the N-terminal free form.
Notes:
Das vollständig geschützte Cysteinpeptid Trt-Val-Cys(Trt)-Ser(But)-Leu-Tyr(But)-Gln-Leu-Glu(OBut)-Asn-Tyr(But)-Cys(Trt)-Asn-OBut (13), dessen Aminosäurefolge der Sequenz A 10-21 der Schafinsulin-A-Kette entspricht, wurde durch Fragmentkondensationen aufgebaut und durch Behandlung mit Jod in Methanol in das entsprechende Cystinpeptidderivat 14 in N-terminal freier Form übergeführt.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.197419740214
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