Publication Date:
2011-05-11
Description:
Jatrophodione A ( 1 ), a new diterpene with four rings, together with nine known compounds, caniojane ( 2 ), jatropholone A ( 3 ), jatropholone B ( 4 ), jatrogrossidione ( 5 ), 2-epijatrogrossidione ( 6 ), heudelotinone ( 7 ), gossweilone ( 8 ), (3 α )-3-hydroxy- ent- pimara-8(14),15-dien-12-one ( 9 ), and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one ( 10 ), was isolated from the aerial parts of Jatropha curcas. Compounds 5, 6, 9 , and 10 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1, 2, 7, 8 , and 9 were tested on the three cancer cell lines A549, Hela, and SMMC-7721. Results showed that 7 exhibited cytotoxicity against SMMC-7721 with an IC 50 value of 21.68 μ M , whereas 7 and 8 were active against A549 with the IC 50 values of 16.04 and 20.47 μ M , and against Hela with the IC 50 values of 10.67 and 22.83 μ M , respectively.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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