Publication Date:
1985-04-05
Description:
The genes encoding the alpha chain of the human T-cell receptor have been mapped to chromosome 14, the chromosome on which the human immunoglobulin heavy chain locus resides. Thus, genes encoding two different classes of antigen receptor are present on the same chromosome. Furthermore, breaks involving chromosome 14 are frequently seen in tumors of T-cell origin. The potential relation of these chromosome abnormalities to alpha-chain genes is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, C -- Morse, H G -- Kao, F T -- Carbone, A -- Palmer, E -- CA-18734/CA/NCI NIH HHS/ -- HD-02080/HD/NICHD NIH HHS/ -- HD-17717/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):83-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3919444" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosome Aberrations
;
Chromosome Disorders
;
*Chromosome Mapping
;
*Chromosomes, Human, 13-15
;
Cricetinae
;
Cricetulus
;
DNA/genetics
;
Humans
;
Immunoglobulin Heavy Chains/*genetics
;
Immunoglobulin alpha-Chains/*genetics
;
Leukemia/genetics
;
Lymphoma/genetics
;
Nucleic Acid Hybridization
;
Receptors, Antigen, T-Cell/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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