Publication Date:
1997-05-16
Description:
Magnaporthe grisea is a fungal pathogen with two mating types, MAT1-1 and MAT1-2, that forms a specialized cell necessary for pathogenesis, the appressorium. Saccharomyces cerevisiae alpha-factor pheromone blocked appressorium formation in a mating type-specific manner and protected plants from infection by MAT1-2 strains. Experiments with alpha-factor analogs suggest that the observed activity is due to a specific interaction of alpha-factor with an M. grisea receptor. Culture filtrates of a MAT1-1 strain contained an activity that inhibited appressorium formation of mating type MAT1-2 strains. These findings provide evidence that a pheromone response pathway exists in M. grisea that can be exploited for plant protection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beckerman, J L -- Naider, F -- Ebbole, D J -- GM22086/GM/NIGMS NIH HHS/ -- R29GM47977/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 May 16;276(5315):1116-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843-2132, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9148806" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Ascomycota/cytology/pathogenicity/*physiology
;
Crosses, Genetic
;
Cyclic AMP/pharmacology
;
Hordeum/microbiology
;
Molecular Sequence Data
;
Oryza/microbiology
;
Peptides/metabolism/*pharmacology
;
Pheromones/metabolism/*pharmacology
;
Plant Diseases/microbiology
;
Receptors, Mating Factor
;
Receptors, Peptide/metabolism
;
Saccharomyces cerevisiae/*chemistry
;
*Transcription Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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