Publication Date:
1987-10-23
Description:
The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene in labeled platelet membranes, an index of membrane fluidity, identifies a prominent subgroup of patients with Alzheimer's disease who manifest distinct clinical features. In a family study, the prevalence of this platelet membrane abnormality was 3.2 to 11.5 times higher in asymptomatic, first-degree relatives of probands with Alzheimer's disease than in neurologically healthy control subjects chosen without regard to family history of dementia. The pattern of the platelet membrane abnormality within families was consistent with that of a fully penetrant autosomal dominant trait. Thus, this abnormality of platelet membranes may be an inherited factor that is related to the development of Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zubenko, G S -- Wusylko, M -- Cohen, B M -- Boller, F -- Teply, I -- AG03705/AG/NIA NIH HHS/ -- AG05133/AG/NIA NIH HHS/ -- MH30915/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1987 Oct 23;238(4826):539-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3659926" target="_blank"〉PubMed〈/a〉
Keywords:
Aged
;
Alzheimer Disease/blood/*genetics
;
Blood Platelets/*ultrastructure
;
Cell Membrane/physiology
;
Diphenylhexatriene
;
Female
;
Fluorescence Polarization
;
Humans
;
Male
;
*Membrane Fluidity
;
Middle Aged
;
Risk Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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