ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Adaptive protein evolution in Drosophila (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 415 (2002), S. 1022-1024 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level, but it has remained unclear how ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/4151022a
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The muddle about mutations (1997)
    [s.l.] : Nature Publishing Group
    Nature 387 (1997), S. 135-136 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Deleterious mutations are genetic changes that decrease fertility or the probability of survival - that is, they decrease fitness. Most evolutionary biologists believe that deleterious mutations that decrease fitness by more than one per cent are common in multicellular plants and animals, arising ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/387135a0
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    High genomic deleterious mutation rates in hominids (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 397 (1999), S. 344-347 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been suggested that humans may suffer a high genomic deleterious mutation rate,. Here we test this hypothesis by applying a variant of a molecular approach to estimate the deleterious mutation rate in hominids from the level of selective constraint in DNA sequences. Under conservative ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/16915
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Problems with Parsimony in Sequences of Biased Base Composition (1998)
    Springer
    Journal of molecular evolution 47 (1998), S. 686-690 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Parsimony — G + C content — Base composition — Substitution pattern — Mutation pattern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Parsimony is commonly used to infer the direction of substitution and mutation. However, it is known that parsimony is biased when the base composition of the DNA sequence is skewed. Here I quantify this effect for several simple cases. The analysis demonstrates that parsimony can be misleading even when levels of sequence divergence are as low as 10%; parsimony incorrectly infers an excess of common to rare changes. Caution must therefore be excercised in the use of parsimony.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006427
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Patterns of Base Composition Within the Genes of Drosophila melanogaster (1998)
    Springer
    Journal of molecular evolution 46 (1998), S. 534-541 
    Details
    ISSN: 1432-1432
    Keywords: Key words: G+C content — Isochores — Synonymous codon use
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Base composition is not uniform across the genome of Drosophila melanogaster. Earlier analyses have suggested that there is variation in composition in D. melanogaster on both a large scale and a much smaller, within-gene, scale. Here we present analyses on 117 genes which have reliable intron/exon boundaries and no known alternative splicing. We detect significant heterogeneity in G+C content among intron segments from the same gene, as well as a significant positive correlation between the intron and the third codon position G+C content within genes. Both of these observations appear to be due, in part, to an overall decline in intron and third codon position G+C content along Drosophila genes with introns. However, there is also evidence of an increase in third codon position G+C content at the start of genes; this is particularly evident in genes without introns. This is consistent with selection acting against preferred codons at the start of genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006334
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    An analysis of codon usage in mammals: Selection or mutation bias? (1991)
    Springer
    Journal of molecular evolution 33 (1991), S. 442-449 
    Details
    ISSN: 1432-1432
    Keywords: Humans ; Mouse ; Rat ; Codon usage ; Mutation bias ; Selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A new statistical test has been developed to detect selection on silent sites. This test compares the codon usage within a gene and thus does not require knowledge of which genes are under the greatest selection, that there exist common trends in codon usage across genes, or that genes have the same mutation pattern. It also controls for mutational biases that might be introduced by the adjacent bases. The test was applied to 62 mammalian sequences, the significant codon usage biases were detected in all three species examined (humans, rats, and mice). However, these biases appear not to be the consequence of selection, but of the first base pair in the codon influencing the mutation pattern at the third position.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02103136
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Synonymous substitutions are clustered in enterobacterial genes (1994)
    Springer
    Journal of molecular evolution 39 (1994), S. 448-451 
    Details
    ISSN: 1432-1432
    Keywords: Synonymous substitution ; Escherichia coli ; Salmonella typhimurium ; Mutation ; Recombination ; Selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The spatial distribution of synonymous substitutions in enterobacterial genes is investigated. It is shown that synonymous substitutions are significantly clustered in such a way that a synonymous substitution in one codon elevates the rate of synonymous substitution in an adjacent codon by about 10%. The level of clustering does not appear to be related to the level of gene expression, and it is restricted to a range of two or three codons. There are at least three possible explanations: (1) sequence-directed mutagenesis, (2) recombination, and (3) selection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173413
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    The Close Proximity of Escherichia coli Genes: Consequences for Stop Codon and Synonymous Codon Use (1996)
    Springer
    Journal of molecular evolution 42 (1996), S. 73-78 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Synonymous codons — Stop codons — Shine-Dalgarno —Escherichia coli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. It is shown that synonymous codon usage is less biased in favor of those codons preferred by highly expressed genes at the end of Escherichia coli genes than in the middle. This appears to be due to the close proximity of many E. coli genes. It is shown that a substantial number of genes overlap either the Shine-Dalgarno sequence or the coding sequence of the next gene on the chromosome and that the codons that overlap have lower synonymous codon bias than those which do not. It is also shown that there is an increase in the frequency of A-ending codons, and a decrease in the frequency of G-ending codons at the end of E. coli genes that lie close to another gene. It is suggested that these trends in composition could be associated with selection against the formation of mRNA secondary structure near the start of the next gene on the chromosome. Stop codon use is also affected by the close proximity of genes; many genes are forced to use TGA and TAG stop codons because they terminate either within the Shine-Dalgarno or coding sequence of the next gene on the chromosome. The implications these results have for the evolution of synonymous codon use are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02198830
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Does very short patch (VSP) repair efficiency vary in relation to gene expression levels? (1995)
    Springer
    Journal of molecular evolution 40 (1995), S. 705-706 
    Details
    ISSN: 1432-1432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00160520
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    The close proximity ofEscherichia coli genes: Consequences for stop codon and synonymous codon use (1996)
    Springer
    Journal of molecular evolution 42 (1996), S. 73-78 
    Details
    ISSN: 1432-1432
    Keywords: Synonymous codons ; Stop codons ; Shine-Dalgarno ; Escherichia coli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract It is shown that synonymous codon usage is less biased in favor of those codons preferred by highly expressed genes at the end ofEscherichia coli genes than in the middle. This appears to be due to the close proximity of manyE. coli genes. It is shown that a substantial number of genes overlap either the Shine-Dalgarno sequence or the coding sequence of the next gene on the chromosome and that the codons that overlap have lower synonymous codon bias than those which do not. It is also shown that there is an increase in the frequency of A-ending codons, and a decrease in the frequency of G-ending codons at the end ofE. coli genes that lie close to another gene. It is suggested that these trends in composition could be associated with selection against the formation of mRNA secondary structure near the start of the next gene on the chromosome. Stop codon use is also affected by the close proximity of genes; many genes are forced to use TGA and TAG stop codons because they terminate either within the Shine-Dalgarno or coding sequence of the next gene on the chromosome. The implications these results have for the evolution of synonymous codon use are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02198830
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...