Publication Date:
2012-11-16
Description:
Abstract 2103 Background: Recent studies suggest that patients with sickle cell disease (SCD) have profound vitamin D (VD) deficiency. Limited data exist on the effect of VD deficiency on bone fragility in these patients. Objectives: To assess the prevalence of VD deficiency in adults with SCD and its consequences on bone metabolism and fragility. Methods: This prospective study included 56 SCD adult patients (mean age 29.8 ± 9.5 years), in a clinically steady state. Clinical and laboratory data were recorded. Bone mineral density (BMD) was measured using dual X-ray absorptiometry. Fracture history, BMD, avascular osteonecrosis, H-shaped vertebra and markers of mineral metabolism were compared between two groups of patients presenting very low (≤6 ng/ml, n=26) (group 1) and low (〉6 ng/ml, n=26) (group 2) 25(OH)D concentration, respectively. Results: Median 25(OH)D concentration was 6 ng/mL. VD deficiency (25(OH)D
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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