ISSN:
1588-2780
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Energy, Environment Protection, Nuclear Power Engineering
Notes:
Abstract The present investigation deals with a study of the isotope exchange reaction of iodine between sodium iodide [Na131I] and [4-127I]iodoantipyrine in organic medium, using different iodinating radioiodine reagents of different carrier-iodine concentration. A maximum saturation yield over 90% of pure [4-131I]iodoantipyrine has been obtained by performing the isotope exchange reaction in ethanol at 80°C in 30 min. The same yield has been obtained using the same concentrations by performing the reaction at room temperature (17–20°C) for 3 h. Also the rate of the isotope exchange reaction was found to be carrier-iodine dependent as well as time and temperature dependent. According to these results and reaction conditions, a kit form method was elaborated for the synthesis of [4-131I]iodoantipyrine as well as [4-123I]iodoantipyrine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02176875
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