ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
4-Acetyl-3-chloro-5,6-diphenylpyridazine (1), prepared by the action of phosphorus oxychloride on 4-acetyl-5,6-diphenylpyridazin-3(2H)-one (2), reacts with hydrazine hydrate and phenylhydrazine to give the pyrazolinopyridazine derivatives (3a, b) respectively. Reaction of 1 with hydroxylamine hydrochloride gave the isoxazolopyridazine derivative (5), while its reaction with sodium azide in dimethyl formamide gave the tetrazolopyridazine derivative (8). Primary amines react with 1 to give either 9 or 10 depending upon the reaction conditions. Treatment of 1 with piperidine or morpholine gave the products 11a, b, respectivly. 4-Acetyl-5,6-diphenylpyridazin-3(2H)-thione (13) was readily obtained by the action of thiourea on ethanolic solution of 1. The reactions of 1 with phenols were also investigated.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19893310308
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