Publication Date:
2013-05-11
Description:
Plasmodium falciparum transmission by Anopheles gambiae mosquitoes is remarkably efficient, resulting in a very high prevalence of human malaria infection in sub-Saharan Africa. A combination of genetic mapping, linkage group selection, and functional genomics was used to identify Pfs47 as a P. falciparum gene that allows the parasite to infect A. gambiae without activating the mosquito immune system. Disruption of Pfs47 greatly reduced parasite survival in the mosquito, and this phenotype could be reverted by genetic complementation of the parasite or by disruption of the mosquito complement-like system. Pfs47 suppresses midgut nitration responses that are critical to activate the complement-like system. We provide direct experimental evidence that immune evasion mediated by Pfs47 is critical for efficient human malaria transmission by A. gambiae.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807741/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807741/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Molina-Cruz, Alvaro -- Garver, Lindsey S -- Alabaster, Amy -- Bangiolo, Lois -- Haile, Ashley -- Winikor, Jared -- Ortega, Corrie -- van Schaijk, Ben C L -- Sauerwein, Robert W -- Taylor-Salmon, Emma -- Barillas-Mury, Carolina -- ZIA AI000947-09/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):984-7. doi: 10.1126/science.1235264. Epub 2013 May 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661646" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anopheles gambiae/*immunology/*parasitology
;
Gene Knockout Techniques
;
Humans
;
Immune System
;
Malaria, Falciparum/*parasitology/*transmission
;
Membrane Glycoproteins/genetics/*physiology
;
Plasmodium falciparum/genetics/*pathogenicity
;
Protozoan Proteins/genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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