Publication Date:
2010-07-24
Description:
During mitosis in Saccharomyces cerevisiae, senescence factors such as extrachromosomal ribosomal DNA circles (ERCs) are retained in the mother cell and excluded from the bud/daughter cell. Shcheprova et al. proposed a model suggesting segregation of ERCs through their association with nuclear pore complexes (NPCs) and retention of pre-existing NPCs in the mother cell during mitosis. However, this model is inconsistent with previous data and we demonstrate here that NPCs do efficiently migrate from the mother into the bud. Therefore, binding to NPCs does not seem to explain the retention of ERCs in the mother cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khmelinskii, Anton -- Keller, Philipp J -- Lorenz, Holger -- Schiebel, Elmar -- Knop, Michael -- England -- Nature. 2010 Jul 22;466(7305):E1. doi: 10.1038/nature09255.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20651645" target="_blank"〉PubMed〈/a〉
Keywords:
Chromosome Segregation/physiology
;
DNA, Fungal/*metabolism
;
DNA, Ribosomal/metabolism
;
*Mitosis
;
Nuclear Pore/*metabolism
;
Nuclear Pore Complex Proteins/analysis/genetics/metabolism
;
Saccharomyces cerevisiae/*cytology/*metabolism
;
Saccharomyces cerevisiae Proteins/analysis/genetics/metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink