Publication Date:
2006-08-12
Description:
Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This trait is linked to a widely spread genomic island that encodes giant modular nonribosomal peptide and polyketide synthases. Contact with E. coli expressing this gene cluster causes DNA double-strand breaks and activation of the DNA damage checkpoint pathway, leading to cell cycle arrest and eventually to cell death. Discovery of hybrid peptide-polyketide genotoxins in E. coli will change our view on pathogenesis and commensalism and open new biotechnological applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nougayrede, Jean-Philippe -- Homburg, Stefan -- Taieb, Frederic -- Boury, Michele -- Brzuszkiewicz, Elzbieta -- Gottschalk, Gerhard -- Buchrieser, Carmen -- Hacker, Jorg -- Dobrindt, Ulrich -- Oswald, Eric -- New York, N.Y. -- Science. 2006 Aug 11;313(5788):848-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INRA, UMR1225, Ecole Nationale Veterinaire de Toulouse, Toulouse F-31076, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16902142" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Ataxia Telangiectasia Mutated Proteins
;
Cell Cycle
;
Cell Cycle Proteins/metabolism
;
Cell Death
;
Cell Line
;
Cell Nucleus/chemistry
;
Cytotoxins/*metabolism
;
DNA/analysis
;
*DNA Damage
;
DNA-Binding Proteins/metabolism
;
Escherichia coli/genetics/*pathogenicity/*physiology
;
G2 Phase
;
*Genomic Islands
;
HeLa Cells
;
Histones/metabolism
;
Humans
;
Intestinal Mucosa/cytology/microbiology
;
Molecular Sequence Data
;
Mutagenesis
;
Mutagens/*metabolism
;
Peptides/*metabolism
;
Phosphorylation
;
Polyketide Synthases/genetics
;
Protein-Serine-Threonine Kinases/metabolism
;
Rats
;
Signal Transduction
;
Tumor Suppressor Proteins/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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